To start Microsoft Outlook in Safe Mode, there are a few options. The first option is to hold down the CTRL key while opening the program, which will launch Outlook with all add-ins disabled. This can help troubleshoot potential issues. Another option is to use the "Run" command and type "outlook.exe /safe" to start Outlook in Safe Mode. If you find that you frequently need to start Outlook in Safe Mode, you can create a shortcut with the "/safe" command for easier access.